Michael Addition Reaction | Mechanism, Examples and Applications | Michael Addition 1,4 Addition
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Michael Addition Reaction | Mechanism, Examples and Applications | Michael Addition 1,4 Addition
Introduction to Michael Addition What is Michael Addition? The Michael Addition is a type of nucleophilic addition reaction. In this reaction, a nucleophile (an electron-rich species) adds to an α,β-unsaturated carbonyl compound (a molecule that has a carbon–carbon double bond next to a carbonyl group, like –C=O). This reaction was ...
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Organic Name Reactions on Instagram: "The Michael addition enables the conjugate (1,4-) addition of carbon nucleophiles to α,β-unsaturated compounds, forming new C–C bonds via attack at the β-carbon. Typical C-nucleophiles include enolates, stabilized carbanions (e.g., malonates, β-dicarbonyls, etc.), and organocuprates. First described by Arthur Michael in the late 19th century, the reaction proceeds through enolate addition to the activated alkene followed by protonation, favoring thermodynami
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