In this review, we recapitulate the current knowledge about the structural, folding stability, and binding properties of SH2 domains and their roles in molecular pathways and pathogenesis. …

SH2 domains, and other binding domains, have been used in protein engineering to create protein assemblies. Protein assemblies are formed when several proteins bind to one another …

Dec 23, 2025 · Src-homology 2 (SH2) domains are modules of approximately 100 amino acids that bind to specific phospho (pY)-containing peptide motifs. Conventional SH2 domains have …

Jun 16, 2025 · In the immune system, SH2 domains are involved in how cells respond to cytokines, which are molecules that signal inflammation and immune activation. Proteins like …

Sep 18, 2020 · Below, we highlight some of the mechanisms SH2 domains use to select binding partners and discuss diversity within the pTyr binding site, starting with ancestral SH2 domains …

The SH2 domain is defined as a protein module that forms a pocket for binding phosphorylated tyrosine residues, facilitating interactions with specific amino acid sequences downstream, and …

Dec 15, 2022 · In this review, we recapitulate the current knowledge about the structural, folding stability, and binding properties of SH2 domains and their roles in molecular pathways and …

Jan 15, 2017 · In this chapter, we provide a glimpse of the history of SH2 domains and describe many of the tools and techniques that have been developed along the way and discuss future …

Feb 15, 2024 · The SH2 domain of SOCS2 serves as a substrate receptor, which binds pTyr on cytokine receptors and other proteins, triggering their ubiquitylation and degradation.

Here, we describe the origin and evolution of SH2 domain proteins by means of sequence analysis from 21 eukaryotic organisms from the basal unicellular eukaryotes, where SH2 …