In this review, we summarize the physiological roles of EP4, its molecular structure and intracellular signaling pathways, and how EP4 receptors might be targeted pharmacologically for the benefit of …

In humans, mRNA for EP4 has been detected by northern blotting in the heart and small intestine and to lesser extents in lung, kidney, thymus, uterus, dorsal root ganglions, and brain.

EP4 is the most recently identified subtype of the EP receptor, having been discovered in the piglet saphenous vein (Coleman et al., 1994a) as an EP receptor insensitive to the agonists of EP1, EP2, …

Human prostaglandin E2 receptor 4 (EP4) is one of the four subtypes of prostaglandin E2 (PGE2) receptors and belongs to the rhodopsin-type G protein-coupled receptor (GPCR) family.

The present review attempts to summarize the EP4 receptor-triggered signaling modules and the possible therapeutic applications of EP4-selective agonists and antagonists.

4 days ago · The couple's 'Love Story' took center stage when the Kennedy scion and the Calvin Klein publicist met in 1992 during a fitting.

Nov 1, 2024 · In this study, we investigate the gene expression signature associated with EP4 and EP2 expression in immune cells infiltrating human cancers using single-cell RNA sequencing (scRNAseq).

Feb 1, 2025 · These observations indicate that the EP4 receptor is a modulator of insulin action and that it contributes to fatty-acid-induced insulin resistance in skeletal muscle cells. Our findings suggest …

Jun 21, 2024 · EP4 agonists operate by binding to and activating the EP4 receptors, which are part of the broader family of prostanoid receptors. These receptors are involved in several physiological and …

Thanks to its expertise in GPCR drug discovery, Domain Therapeutics discovered series of small molecule EP4 receptor antagonist. Among them, the candidate DT-9081 has been selected and is …