The TP53 gene is mutated in around 50% of cancer cells, but in addition to its role in tumor suppression, cancer cells ...

Among patients with chondrosarcomas, the most common primary bone tumor in adults, the presence of a TP53 gene mutation has been found to be associated with worse overall survival and metastasis-free ...

Long-Term Follow-Up of Patients With Follicular Lymphoma Receiving Single-Agent Rituximab at Two Different Schedules in Trial SAKK 35/98 We assessed TP53 mutations by denaturing high-performance ...

—A study of 1230 individuals with chronic lymphocytic leukemia and high-count monoclonal B-cell lymphocytosis demonstrated that patients with wild type TP53 had longer time to first treatment and ...

What is Li-Fraumeni syndrome? Li-Fraumeni syndrome (LFS) is a genetic condition that increases the risk of developing many different types of cancers. What causes Li-Fraumeni syndrome? LFS is caused ...

Dr Garcia-Manero discusses the effects of TP53 mutation in patients with MDS. I don’t have an answer to your question. We don’t understand why this has become so refractory to therapies. It’s like ...

In a recent study published in Nature Genetics, researchers performed an allelic-level single-cellular multi-omics evaluation of hematopoietic stem/progenitor cells (HSPCs) obtained from individuals ...

The TP53 gene is one of the most important tumor suppressor genes in the human body. It plays a key role in controlling cell division, repairing DNA damage, and preventing abnormal cell growth. When ...

Significant treatment options are changing the management of CLL, according to research presented at the ASH Annual Meeting 2025.