The heart and brain are among the earliest and most metabolically demanding organs in human development. Though historically studied in isolation, both ...

Recent advances in single-cell sequencing and spatial multi-omics have transformed our ability to resolve tumor ecosystems at unprecedented resolution.

Single-cell multimodal omics technologies have empowered the profiling of complex biological systems at a resolution and scale that were previously unattainable. These biotechnologies have propelled ...

Breast cancer remains the most commonly diagnosed malignancy worldwide and constitutes a major contributor to cancer-related mortality among women 1. Despite continuous advancements in therapeutic ...

Cancer immunotherapy has reshaped oncology by harnessing the immune system to target and eliminate malignant cells. Treatments such as immune checkpoint inhibitors and adoptive T-cell therapies have ...

In a recent review published in the European Journal of Immunology, a group of authors summarized current advances, challenges, and future directions in human systems immunology using multi-omics ...

This illustration summarizes how integrated spatial transcriptomics, single-cell transcriptomics, single-cell epigenomics, and spatial epigenomics enable multi-dimensional profiling of the tumor ...

A new tool developed by Weill Cornell Medicine and the University of Adelaide investigators has enhanced the ability to track multiple gene mutations while simultaneously recording gene activity in ...

Over the past two decades, high‑throughput sequencing has dramatically expanded our understanding of the gut microbiome's composition.

Single-cell RNA-seq (scRNA-seq) has spent the past decade maturing into a foundational technology. Over that time, the technology has both laid the foundation for building cell atlases and allowed ...

Estimating the cell type composition in a tissue sample using bulk data is a major challenge in cancer research. To address this, researchers at Oregon Health & Science University (OHSU) have ...

The gut microbiome is not a mere spectator but an active player in colorectal cancer (CRC), driving tumor initiation and ...