Current medical imaging technology misses important data regarding muscle contraction, including the ways in which a muscle's shape changes when it contracts, how the muscle bulges, and how its ...
The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...
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Genetic model reveals a form of calcium release is unnecessary for normal muscle contraction
The research team developed a genetically engineered mouse model carrying a mutation (E3896A) in RyR1, which disrupts its calcium-binding site, effectively disabling CICR while preserving ...
Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people. While it is well known for causing muscle weakness and stiffness, DM1 also ...
“This article illuminates the biology behind EDG-5506, demonstrating that modulation of fast skeletal muscle contraction protects against muscle injury, degeneration and fibrosis in models of DMD,” ...
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