Phosphatidate phosphatase (PAP) enzymes play a pivotal role in lipid metabolism, acting as a control point that directs metabolic flux between membrane phospholipid synthesis and the production of ...

The brain is the body's command center, and neurons are the workhorses that carry out its commands. They transmit signals ...

Faulty lipid regulation in CLL patients impairs T-cell function, affecting treatment outcomes and resistance to current therapies. Differences in lipid metabolism between CLL patients and healthy ...

Lipid metabolism has emerged as a central player in the progression and therapy resistance of breast cancer, particularly the aggressive subtype known as triple-negative breast cancer (TNBC). This ...

Lipid research investigates the structure, function and metabolism of fats, covering their roles in industrial processes, the environment and health. Emerging research areas include nutrient ...

Certain lipids discovered in the 1800s presented chemists with structural and functional puzzles that proved unsolvable. And so, the chemists called these lipids sphingolipids, likening them to the ...

Losing body fat is not always healthy. A new study shows fat loss can disrupt metabolism, trigger inflammation, and increase ...

Modern medicine is improving in precision, identifying exactly who needs treatment and who doesn’t. In heart disease ...

Cholesterol drugs do more than move numbers. This deep dive into bempedoic acid explores a newly discovered PPARα mechanism, implications for inflammation and brain health, and how I make medical deci ...

A deeper look at what one supercentenarian’s labs can teach us about aging, cholesterol, and what really matters for ...