Gene therapy holds the promise of preventing and curing disease by manipulating gene expression within a patient's cells.

For decades, biologists have known that the instructions for life are written in DNA, yet the vast majority of those letters seemed to sit in the dark, doing little that was obvious. Now a new ...

Once disregarded as “junk DNA,” scientists now know that this molecular dark matter is crucial for determining gene activity ...

Much of the phenotypic variation that is observed within and between species is the result of differences in gene regulation: specifically when, where and how much the genes are expressed. Given the ...

Epigenetics is a rapidly growing field of study that focuses on the heritable changes in gene expression that occur without alterations to the underlying DNA sequence. These changes are caused by ...

It could transform our understanding of why diseases develop and the medicines needed to treat them, says researchers.

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

Researchers at the Jackson Laboratory (JAX), the Broad Institute of MIT and Harvard, and Yale University, have used artificial intelligence (AI) to design thousands of new DNA switches that can ...

Scientists at the Broad Institute and Mass General Brigham have built a generative AI model that creates short DNA segments ...

All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics—meticulously placed chemical tags that influence which genes are expressed in ...

Epigenetics is the study of various heritable alterations that control gene expression without changing the DNA sequence. 1 The name epigenetics comes from the Greek prefix “epi”, which means on top ...