Within contemporary molecular biology, the regulation of tissue growth has emerged as a central theme linking developmental signaling, metabolic balance, and structural adaptation. Among the molecular ...

New research combines two powerful imaging techniques to study the complete structure of a common aGPCR, including how its long and complex extracellular region interacts with the transmembrane region ...

Over the last decade, antibodies that block extracellular receptors on our immune cells have redefined the treatment approach for certain cancers. Now, all eyes are on how using the opposite approach ...

Therapeutics that leverage protein degradation as their primary mechanism of action appear to be a validated new therapeutic modality. The current clinical molecules are focused on degrading ...

This original animation illustrates that presynaptic neurons secrete VLK, which then phosphorylates the extracellular side of ephrin type-B receptor 2 (EphB2) extruding from the membranes of ...

Studies of signal transduction have yielded a wealth of information about the molecules required to transmit signals from the cell surface to the nucleus. Yet it still remains unknown how a signaling ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

Almost 35% of drugs approved by the Food and Drug Administration work by targeting G protein-coupled receptors (GPCRs), proteins embedded in cell membranes that allow cells to communicate with each ...

Adhesion G protein-coupled receptors have a large extracellular region (shown in green and orange) that extends into space outside the cell. Almost 35% of drugs approved by the Food and Drug ...