The ERBB receptors are a group of receptor tyrosine kinases (RTKs) involved in key cellular functions including cell growth and survival. What are the activation mechanisms particular to ERBBs? To ...
Sequence analysis of BRCA1 and BRCA2: correlation of mutations with family history and ovarian cancer risk. Plasma c-erbB-2 levels varied widely in breast cancer patients. In general, when all ...
ErbB-2 overexpression in breast tumors is associated with poor survival. Expression of Notch-1 and its ligand, Jagged-1, is associated with the poorest survival, including ErbB-2-positive tumors.
Mortality Associated With Irinotecan Plus Bolus Fluorouracil/Leucovorin: Summary Findings of an Independent Panel PURPOSE: Expression of ErbB-1 and ErbB-2 (epidermal ...
The Clinical Implications of Basic Research series has focused on highlighting laboratory research that could lead to advances in clinical therapeutics. However, the path between the laboratory and ...
The ErbB family of cell surface receptors is involved in the transduction of cellular growth and proliferation signals; ErbB-1 and ErbB-2, for example, have been implicated in aggressive forms of ...
A team of scientists from the USA and Belgium has recently revealed that the ErbB family of receptor tyrosine kinases play a vital role in regulating severe acute respiratory syndrome coronavirus 2 ...
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