Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for ...

In preliminary experiments with mice and lab-grown cells, Johns Hopkins Kimmel Cancer Center scientists have found that a protein-signaling process accelerates the work of the gene most frequently ...

An international research team reveals new molecular mechanisms associated with pathogenic mutations in the protein ...

Co-founded by Jennifer Doudna and Fyodor Urnov, the company intends to simultaneously develop many gene editing treatments ...

Advanced prostate cancer has a new treatment option, a Johnson & Johnson drug that combines two of the company’s therapies in a single pill. Niraparib is small molecule designed to block PARP, an ...

Developing high-quality, safe, and effective drugs is a complex process that requires varied scientific skills and stringent regulatory assessments. Drug development is a process that spans many years ...

A genetic mutation passed from mother to children in families affected by schizophrenia has now been shown to completely ...

Merck & Co.’s COVID-19 pill is giving rise to new mutations of the virus in some patients, according to a study that underscores the risk of trying to intentionally alter the pathogen’s genetic code.

When he was 4 months old, Leo Wei Church was diagnosed with a gene mutation so rare that his doctors say he is one of two people in the world with this diagnosis. He would bounce between acting like a ...

Scientists have developed a new treatment strategy that could one day save the lives of children affected by aggressive brain stem cancers.

Zoldonrasib targets KRAS G12D-mutated non-small cell lung cancer, receiving FDA breakthrough therapy designation for its ...