I regret to say there is no simple or easy answer to this question. Many people use the word ‘depression’ to refer to normal disappointment or sadness, and there can be little doubt that the concept ...

Several psychiatrists are considering changing guidelines that define depression, due to findings from a new study. Michele Norris talks with Dr. Michael First of Columbia University about expanding ...

“Unspecified depressive disorder” is used when someone displays depressive symptoms, but there isn’t enough information for a specific diagnosis. Depressive symptoms can be complex and may not clearly ...

A new study led by Shan Siddiqi, MD, from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, suggests that depression after traumatic brain injury (TBI) ...

Depression is characterized by a persistent low mood that can affect quality of life. If symptoms usually only occur in the winter months, it may be seasonal affective disorder (SAD), or major ...

Researchers have discovered a surprising change in how cells produce energy in people with depression. Brain and blood cells in young adults with major depressive disorder produced more energy ...

Depression-related fatigue is caused by cellular "overworking" at rest and a failure to produce energy under stress.