Mutations are changes in the molecular "letters" that make up the DNA code, the blueprint for all living cells. Some of these changes can have little effect, but others can lead to diseases, including ...

New research from a team of genome scientists and DNA damage response experts breaks new ground in understanding the function of a protein currently limited in clinical trials for cancer treatments.

A new family of enzymes enables precise cuts in single-stranded DNA, offering powerful new tools for genetic engineering and expanding possibilities in biotechnology. (Nanowerk News) A few years ago, ...

Previously, a similar approach to making biosensors was developed using a single DNA strand rather than a DNA origami ...

An INRS team discovers a new family of enzymes capable of inducing targeted cuts in single-stranded DNA . A few years ago, the advent of technology known as CRISPR was a major breakthrough in the ...

Mutations accumulate in the genome of every cell of the body throughout life, causing cancer and other genetic diseases. Almost all of these mosaic mutations begin as nucleotide mismatches or damage ...

Figure 1. Design and synthesis of circAMO . (a) Synthesis of a single-molecule ring by rigid regulation of selectivity; (b) Schematic diagram of circAMO design; (c) Synthesis of circAMO; (d) ...

Despite its utility, PCR’s main limitation is that it requires precise cycles of heating and cooling to amplify DNA. The thermal cyclers that perform this operation are clunky, relatively expensive, ...

Changes in genes have been linked to the development of different diseases for a while. However, it's not exactly clear what ...