The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region regulating their function, according to a new study from St. Jude Children's ...
The R2TP complex, a specialised co‐chaperone assembly comprising the AAA+ ATPases RUVBL1 and RUVBL2 along with RPAP3 and PIH1D1, is pivotal in orchestrating the assembly and stabilisation of a wide ...
Proteins control most of the body's functions, and their malfunction can have severe consequences, such as neurodegenerative diseases or cancer. Therefore, cells have mechanisms in place to control ...
Proteins control most of the body's functions, and their malfunction can have severe consequences, such as neurodegenerative diseases or cancer. Therefore, cells have mechanisms in place to control ...
Two related studies published today in Nature Metabolism show that a specialized intracellular recycling mechanism—chaperone-mediated autophagy (CMA)—is essential for muscle health. As the body ages, ...
(L to R) Corresponding author Charalampos Babis Kalodimos, PhD, St. Jude Department of Structural Biology chair, and co-first authors Ziad Ibrahim and Youlin Xia, St. Jude Department of Structural ...
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