Autoreceptors provide an important inhibitory feedback mechanism for dopamine neurons by altering neuronal functions in response to changes in extracellular levels of dopamine. Elevated dopamine may ...

Generations of studying the root cause of schizophrenia have largely converged around a single theory: the “dopamine hypothesis,” which postulates that a combination of genetic susceptibility, ...

An extremely important therapeutic advantage of atypical antipsychotic drugs, such as clozapine and olanzapine, is improvement of cognitive function in schizophrenia. It is now acknowledged that trait ...

PITTSBURGH, Oct. 1 – Although drugs that target the brain's serotonin system are widely used to treat depression, the basic biological mechanism by which they help to alleviate symptoms is poorly ...